The drug "Depakin-chrono 300". Reviews, description
The drug "Depakin-chrono 300" is available in tablets that have a prolonged (prolonged) effect. The medication is included in the category of antiepileptic drugs.
Tablets "Depakin-chrono 300" instructionrecommends taking with food without crushing. Preferably, the daily dose is divided by two times. A single use of the drug "Depakin-chrono 300" (expert reviews indicate this) is allowed only with controlled epilepsy.
The drug is different from other drugs of its owngroup by sustained release of the active ingredient. This, in turn, leads to a decrease in the maximum concentration of the active component and contributes to a more even distribution throughout the body throughout the day.
Means "Depakin-chrono 300" (reviews of doctors inthis is the same) is allowed for adults and children whose body weight is more than seventeen kilograms. This dosage form is not recommended for patients under six years of age. For young children the drug "Depakin-chronosphere" was developed. The medication is also available in a suspended form.
The optimal initial dosage of the drug"Depakin-chrono 300" (reviews of specialists testify to this) per day is from ten to fifteen milligrams per kilogram. Subsequently, the amount of the agent is increased.
On average, the dosage per day is twenty to thirtymilligram per kilogram. In the absence of control over epilepsy at this dose, the amount of medicine may be increased. The patient should be supervised by a doctor.
For older people, the dosage is set ataccording to the clinical picture. Despite the fact that the amount of the drug is calculated taking into account the weight of the patient, it is necessary to take into account the individual tolerability of the active component of the drug (valproate).
The drug "Depakin-chrono 300" (reviews of doctors andpatients testify to this) is generally well tolerated. However, side reactions are not excluded. When using the medicine for all undesirable manifestations, it is necessary to inform the doctor immediately. The drug "Depkin-chrono" can provoke cognitive impairment with the development of dementia. These disorders are eliminated for several weeks or months after the last dose.
In some cases, the drug "Depakin-chrono" can cause lethargy or stupor, leading to a coma (transitory). With a reduction in dosage or withdrawal of the drug, these reactions were eliminated.
Very rarely during therapy, development of parkinsonism was noted.
In some cases, the drug "Depakin-chrono"can cause headache, drowsiness, postural tremor (easy), gastralgia, vomiting. Side effects include also disorders of liver, pancreatitis, requiring discontinuation of therapy, pancytopenia, leukopenia, anemia.
When taking the medicine, allergic reactions are likely, erythema multiforme, vasculitis, urticaria, epidermal necrolysis (toxic), rash.
In some cases, there may be a change in body weight, hearing loss (irreversible and reversible), violation of the menstrual cycle and amenorrhea.
Contraindicated in the drug "Depakin-chrono" with hepatitis (acute and chronic), children under six years of age, with pregnancy, lactation, with hypersensitivity.
It is not recommended simultaneous use of the drug with medicines "Meflokhin", "Lamotrigine".
Transition from other antiepileptic drugs tothe drug "Depakin-chrono" needs to be carried out gradually under the control of the doctor, reaching the optimal dosage for at least two weeks. Together with this, taking into account the patient's condition, reduce the amount of the previous medication.
