The preparation "Vikasol": instruction
The drug "Vikasol" (tablets), the instruction indicates, contain 15 mg of bisulphite sodium menadione.
The drug "Vikasol" in the form of a solution for intramuscular administration contains in each ampoule 10 mg of bisulphite sodium menadione.
The drug refers to the clinical and pharmaceuticalhaemostatic group. Pharmaceutical action is based on the fact that the drug "Vikasol" is a synthetically created analogue of vitamin K, soluble in water. Prevents the formation of prothrombin. Beneficial effect on substances involved in blood clotting, activated in the liver; helps restore the process of blood coagulation.
The action of menadione in the body is observed throughtwelve hours after administration. The drug "Vikasol" (tablets) is perfectly absorbed by the body. In the blood interacts with plasma proteins, this process has a reversible character. Depot accumulation of the drug in the body is the liver, spleen, myocardium. At a certain stage of metabolism from bisulfite menadione sodium is formed vitamin K2.
The decomposition products of vitamin K are represented by monosulfates, phosphates and digyducuronid-2-methyl-1,4-naphthoquinone, up to 70% of the residues are excreted in urine.
The drug "Vikasol": instructions for use. Indications
The drug is prescribed:
- with hemorrhagic syndrome associated with hypoprothrombinemia;
- with a lack of vitamin K in the body (patients undergoing treatment for jaundice, hepatitis, cirrhosis, prolonged diarrhea);
- with hemorrhagic disease in newborns;
- with significant blood loss as a result of injury, trauma and surgical intervention;
- with abundant bleeding of the uterus in gynecology;
- with menorrhagia;
- with bleeding caused by taking medications that are part of the group of indirect anticoagulants, as a specific antagonist;
- during pregnancy in the third trimester of pregnancy, to prevent bleeding in newborns;
- in preparation for surgery, after surgery;
- with bleeding caused by a stomach ulcer or duodenal ulcer;
- with abundant hemorrhoidal and nasal bleeding.
The drug "Vikasol": instructions for use. Dosage
The doctor appoints adults for oral administration of bisulfite menadione sodium in a dose of 15 mg to 30 mg. The IM dose is 10 mg to 15 mg.
Children under the age of one year are prescribed a dose of 2-5 mg of the drug.
Children under the age of 2 years are prescribed 6 mg each.
Children from 3 years to 4 years of age are prescribed 8 mg each.
Children from 5 years to 9 years are prescribed 10 mg each.
Children aged 10 to 14 years are prescribed 15 mg each.
The indicated doses of "Vikasol" are prescribed 2-3 times a day. The doctor sets the duration of the treatment course individually.
Do not exceed the daily dose of the drug for adults - 60 mg orally, 30 mg intramuscularly. Do not install a single dose of the drug for adults above 30 mg orally, 15 mg intramuscularly.
The maximum allowable daily dose of the drug "Vikasol" for newborns is 4 mg.
The drug "Vikasol": instructions for use. Side effects
In clinical trials, allergic reactions were rare, which are manifested by skin rash, itching, erythema, urticaria, bronchospasm.
Disturbances in the blood clotting system may be manifested by hemolytic disease of the newborn.
The drug "Vikasol": instructions for use. Contraindications
You can not prescribe the drug:
- with increased blood coagulation;
- with symptoms of thromboembolism;
- with increased sensitivity to bisulfite menadione sodium.
Pregnant women and mothers who are breastfeeding, the drug "Vikasol" is prescribed according to the indications.
special instructions
Patients who have violations,associated with the outflow of bile, the drug is administered parenterally. In the treatment of patients suffering from hemophilia and Verlhof disease, the drug "Vikasol" does not give positive results.
The use of the drug simultaneously with oral anticoagulants reduces the anticoagulant effect.
